Ebook Gene Machine: The Race to Decipher the Secrets of the Ribosome
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Gene Machine: The Race to Decipher the Secrets of the Ribosome
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Everyone has heard of DNA. But by itself, DNA is just an inert blueprint for life. It is the ribosome - an enormous molecular machine made up of a million atoms - that makes DNA come to life, turning our genetic code into proteins and therefore into us.Â
Gene Machine is an insider account of the race for the structure of the ribosome, a fundamental discovery that both advances our knowledge of all life and could lead to the development of better antibiotics against life-threatening diseases.Â
But this is also a human story of Ramakrishnan's unlikely journey, from his first fumbling experiments in a biology lab to being the dark horse in a fierce competition with some of the world's best scientists. In the end, Gene Machine is a frank insider's account of the pursuit of high-stakes science.
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Audible Audiobook
Listening Length: 8 hours and 11 minutes
Program Type: Audiobook
Version: Unabridged
Publisher: HighBridge, a division of Recorded Books
Audible.com Release Date: November 6, 2018
Whispersync for Voice: Ready
Language: English, English
ASIN: B07JQ1PTVM
Amazon Best Sellers Rank:
I have only ever read two books in one sitting; Gene Machine is one of them. As a scientist and former teacher descended from a long line of teachers, I can unreservedly say that Ramakrishnan's writing shows the traits that only the greatest teachers have: an appreciation of what the reader/student may know coming in, a talent for accessibly delivering new and complex knowledge and ideas, a broad and deep reservoir of knowledge to draw from, and a commitment to portraying how acquiring knowledge is as much a personal and societal endeavor as it is a technical exercise.Thanks to the author’s gifts, I was so drawn into the narrative that it felt as if I were experiencing the struggles and victories alongside Venki and his colleagues. Breakfast, lunch, dinner, feeding my cats, all could be ignored - there was important work to do! It made me want to go into the lab and help out, even though, as a biochemist, I knew the ending.But more than an informative, engrossing tale, Gene Machine reveals the deepest, darkest desires and fears that can bedevil the psyche of those who grapple with Mother Nature (as well as each other) to decipher her most fundamental workings. Ramakrishnan shares his feelings, and equally importantly, his feelings about those feelings, with a candor that few people, and I reckon fewer scientists, would ever risk. What shines through in these descriptions is the author's deep affection for the pursuit and a generosity of spirit for all those engaged in that pursuit, "friend" or "foe". There's a lesson in that for all of us: truly committing ourselves to that which is most enduring gives us a much more productive perspective on everything else.I highly recommend this book to anyone, scientist or not, who wants to learn more about what drives people to pursue a deep knowledge of how nature works and what we can do with that knowledge. As science leaps from the lab to our lives, cultures and economies with greater speed and impact every day, it is crucial to understand what is too often misunderstood or misrepresented in our society: the motivations and feelings of those who push themselves to the limit at the cutting edge of discovery. Some of humanity’s greatest blunders have come from failing to understand how scientific research actually works. Gene Machine is a great way to learn about it from a world-class teacher. And it is a jolly good adventure!
Most of the expert reviews of this book mention that it is a modern the successor to James Watson's "The Double Helix"; I would argue that it's a superior page-turner. The story Venki tells is more similar to a novel than nonfiction, which is credit to his skill in making the different scientists and their stories come alive.The only reason this is not a five-star review is because Venki's science writing is... not good. His attempts to explain the details of X-ray diffraction and ribosome mechanics in layman's terms fall totally flat. As a biologist who with casual familiarity with crystallography, even I was totally lost in some parts of his explanations. It turns out that Venki is no Ed Yong.However, the mechanistic details of how crystallography works are generally unimportant to this story. Venki gives a remarkable and unique view into how high-stakes science works in a day-to-day sense, with all the character flaws and triumphant efforts involved. It's a wonderful story that I would recommend to everyone I know.
This “review†is simply to offset lakedog’s. Reviews should be based on the contents of the book, not its price or ancillary matters.
The material content is good. However, the author spends a great deal of ink talking about other people he learned from and worked with. I'm supportive of this in the sense of giving credit where credit is due, but all the "name-dropping" gets in the way of reading about the science of the ribosome. In fact, the science regarding how the ribosome actually looks and works gets short shrift, in my opinion. Most of the book talks about the "how" and "who" of ribosome structural science. There's not nearly enough time spent on describing how all the parts of the ribosome are put together and how the ribosome function fits within the broader context of cellular protein manufacture. There are a few paragraphs about these issues here and there, but not nearly enough that I could walk away from the book understanding more about this intriguing and essential organelle. Compare and contrast this to the book "Life's Vital Force," which does a superlative job of describing the function, evolution and structure of the mitochondria.I want to call out the last chapter and the Epilogue as being exceptionally good. In these sections, Dr. V. Ramakrishnan does a wonderful job talking about the broader social context in which science happens, the way the Nobel Prize changed his life, and the value of science in general. He also summarizes much of the book's prior narrative and talks about new research into ribosomes, RNA and such.I would rather have seen a narrative that focuses more on describing the science, and relegates the information about collaborators etc. to footnotes or endnotes.
I don't know what I was expecting from this book, but what I got was a pretty honest portrait of the author's travels and journey throughout his career in search of the true structure of the ribosome. What I enjoyed about the book is the details included about the ribosome that were provided in greatest depth towards the end of the book, hearing about the amazing dedication of the author to solve a very specific and difficult problem in a timely manner and the author's honesty about his genuine thoughts regarding different events and even colleagues. What I did not like was the amount of name dropping of other scientists and certain conferences that didn't seem very relevant to the overall story. The style of writing is somewhat engaging, but when compared to other science books, this book is not one that I felt that I had to keep on reading because I couldn't wait to hear what happened. Instead I took my time, enjoyed parts of it and have now moved on to more interesting and engaging books. Overall, a solid read but not spectacular.
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